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The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in adults with a body mass index (BMI) greater than 27, given that they also suffer from weight-related medical issues such as Tupe2 diabestes, high cholesterol levels and/or hypertension (high blood pressure levels).Contrave is often a combination of two FDA-approved drugs, naltrexone and bupropion, within an extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder so that as an aid to stopping smoking treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination which has a healthy lifestyle which includes a reduced-calorie dieting and exercise, Contrave provides another treatment choice for chronic weight management for people who are obese or are overweight and possess at least one weight-related health condition.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that consisted of a reduced- calorie diet and regular exercising. Results from a medical trial that enrolled patients without diabetes showed that patients had the average weight loss of four years old.1% in contrast to participants have been given placebos) after a 12- month period, while a separate study involving patients with diabetes type 2 had a normal weight loss of 2% over treatment with placebo at twelve months.

Using two separate drugs to shed weight can be very effective you'll find combinations as you're watching FDA now awaiting approval. When dealing with weight loss and the those who go through it you should err on the side of caution and allow the FDA do its job and demand some research be done so the public knows the side effects and hazards of the medications before we bring them. Keep in mind that drug companies come in business to generate income and that they would say anything to keep people on his or her medications.

Researchers found that participants using this drug for a year, dropped excess weight within one month and have kept the body weight off during the entire 56 weeks of the study. Contrave can be a combination in the drugs naltrexone and bupropion, which appears to reflect a brand new trend of weight-loss drugs which can be made up of several active ingredient, which might make them more potent and safer.

Combo-pilling is the newest fad or better yet the newest ahead under scrutiny and for that reason it is just more publicly known recently, comb-pilling for weight reduction has been around since the eighties. The biggest reason that utilizing a combination of pills is becoming popular could be the fact that since right now there are not any long term prescription weightloss pills that have been approved by the FDA apart from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations are actually rejected or have yet to be authorized by the FDA.

Seizures are a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug could also raise hypertension and heart rate, and must not be used in those with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with the drug.

The FDA also warned that Contrave can raise blood pressure levels and heart rate and must 't be used in patients with uncontrolled high blood pressure, along with by you aren't heart-related and cerebrovascular (blood vessel dysfunction impacting mental performance) disease. Patients having a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes with a boxed warning to alert medical professionals and patients on the increased chance of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stop smoking.


The most common unwanted effects with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.